![JCI - Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease JCI - Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease](https://dm5migu4zj3pb.cloudfront.net/manuscripts/149000/149296/medium/JCI149296.f1.jpg)
JCI - Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease
![PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/265b8d3517575964e518b92944c9558171cdf15d/10-Figure1-1.png)
PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar
![Cancers | Free Full-Text | Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies? | HTML Cancers | Free Full-Text | Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies? | HTML](https://www.mdpi.com/cancers/cancers-13-02611/article_deploy/html/images/cancers-13-02611-g001.png)
Cancers | Free Full-Text | Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies? | HTML
![Efficacy and safety of itacitinib versus placebo in combination with corticosteroids for initial treatment of acute graft-versus-host disease (GRAVITAS-301): a randomised, multicentre, double-blind, phase 3 trial - The Lancet Haematology Efficacy and safety of itacitinib versus placebo in combination with corticosteroids for initial treatment of acute graft-versus-host disease (GRAVITAS-301): a randomised, multicentre, double-blind, phase 3 trial - The Lancet Haematology](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/d80b62af-5efc-412d-ad4e-44c13de223c5/gr2_lrg.jpg)
Efficacy and safety of itacitinib versus placebo in combination with corticosteroids for initial treatment of acute graft-versus-host disease (GRAVITAS-301): a randomised, multicentre, double-blind, phase 3 trial - The Lancet Haematology
![PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/265b8d3517575964e518b92944c9558171cdf15d/7-Table1-1.png)
PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar
![Impact of itacitinib on xGVHD Survival (a), GVHD scoring (b) and weight... | Download Scientific Diagram Impact of itacitinib on xGVHD Survival (a), GVHD scoring (b) and weight... | Download Scientific Diagram](https://www.researchgate.net/publication/352740683/figure/fig1/AS:1038821072334850@1624685652295/Impact-of-itacitinib-on-xGVHD-Survival-a-GVHD-scoring-b-and-weight-loss-c-in-the_Q640.jpg)
Impact of itacitinib on xGVHD Survival (a), GVHD scoring (b) and weight... | Download Scientific Diagram
![A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease - ScienceDirect A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2473952920313562-grabsf1.jpg)
A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease - ScienceDirect
![PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/265b8d3517575964e518b92944c9558171cdf15d/6-Table1-1.png)
PDF] A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease. | Semantic Scholar
![A Phase 1/2 Study of the Oral Janus Kinase 1 Inhibitors INCB052793 and Itacitinib Alone or in Combination With Standard Therapies for Advanced Hematologic Malignancies - Clinical Lymphoma, Myeloma and Leukemia A Phase 1/2 Study of the Oral Janus Kinase 1 Inhibitors INCB052793 and Itacitinib Alone or in Combination With Standard Therapies for Advanced Hematologic Malignancies - Clinical Lymphoma, Myeloma and Leukemia](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/1ce96086-37a0-44a0-817a-ca50f39e1738/gr1_lrg.jpg)
A Phase 1/2 Study of the Oral Janus Kinase 1 Inhibitors INCB052793 and Itacitinib Alone or in Combination With Standard Therapies for Advanced Hematologic Malignancies - Clinical Lymphoma, Myeloma and Leukemia
![Predicting Complete Response to Itacitinib and Corticosteroids in Acute Graft Versus Host Disease - Biology of Blood and Marrow Transplantation Predicting Complete Response to Itacitinib and Corticosteroids in Acute Graft Versus Host Disease - Biology of Blood and Marrow Transplantation](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/58e5908c-33d8-4e21-b42d-41747555aa75/fx2.jpg)
Predicting Complete Response to Itacitinib and Corticosteroids in Acute Graft Versus Host Disease - Biology of Blood and Marrow Transplantation
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Trial in Progress: Gravitas-301, a Randomized, Double-Blind Phase 3 Study of Itacitinib or Placebo with Corticosteroids (CS) for the First-Line Treatment of Patients with Acute Gvhd (aGVHD) - Biology of Blood and
![VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease | 2 Minute Medicine VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease | 2 Minute Medicine](https://www.2minutemedicine.com/wp-content/uploads/2022/01/2MM-VA-1.2.22_1_GVHDitacitinib-scaled.jpg)
VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease | 2 Minute Medicine
![Ruxolitinib for the treatment of patients with steroid-refractory GVHD: an introduction to the REACH trials | Immunotherapy Ruxolitinib for the treatment of patients with steroid-refractory GVHD: an introduction to the REACH trials | Immunotherapy](https://www.futuremedicine.com/cms/10.2217/imt-2017-0156/asset/images/medium/figure1.gif)
Ruxolitinib for the treatment of patients with steroid-refractory GVHD: an introduction to the REACH trials | Immunotherapy
A Phase 2, Double-Blind, Dose-Ranging, Placebo-Controlled Study With Open-Label Extension to Evaluate the Safety and Efficacy of Itacitinib in Moderate to Severe Ulcerative Colitis | Clinical Research Trial Listing ( Ulcerative Colitis ) (
![Incyte Announces Results of Phase 3 Study of Itacitinib in Patients with Treatment-Naïve Acute Graft-Versus-Host Disease | Business Wire Incyte Announces Results of Phase 3 Study of Itacitinib in Patients with Treatment-Naïve Acute Graft-Versus-Host Disease | Business Wire](https://mms.businesswire.com/media/20200102005480/en/3588/23/Incyte_2CPos_RGB.jpg)
Incyte Announces Results of Phase 3 Study of Itacitinib in Patients with Treatment-Naïve Acute Graft-Versus-Host Disease | Business Wire
![The Lancet Haematology on Twitter: "Zeiser also discussed GRAVITAS-301: addition of itacitinib, a JAK1 inhibitor, did not improve response compared with standard first line therapy for acute #GVHD. Corticosteroids remain the standard The Lancet Haematology on Twitter: "Zeiser also discussed GRAVITAS-301: addition of itacitinib, a JAK1 inhibitor, did not improve response compared with standard first line therapy for acute #GVHD. Corticosteroids remain the standard](https://pbs.twimg.com/media/EapBWqAX0AAM4XN.jpg:large)
The Lancet Haematology on Twitter: "Zeiser also discussed GRAVITAS-301: addition of itacitinib, a JAK1 inhibitor, did not improve response compared with standard first line therapy for acute #GVHD. Corticosteroids remain the standard
![Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study | Journal for ImmunoTherapy of Cancer Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study | Journal for ImmunoTherapy of Cancer](https://jitc.bmj.com/content/jitc/10/3/e004223/F2.large.jpg)